This was the first time that 'Acquired Immunodeficiency Syndrome' (AIDS), the devastating advanced-stage of HIV infection that would go on to claim the lives of more than 32 million people globally, was reported in the US.

Deotis McMather is pictured asleep in bed at the San Francisco General Hospital's Ward 5B -- the first AIDS hospital unit in the nation. After being diagnosed with AIDS, he returned to his apartment, where all of his belongings had been thrown out onto the street.

Days after the initial report hit the newspapers, the CDC learned of many more such cases in gay men. Not only did those men have PCP, they also had other secondary infections, among them a rare and aggressive cancer known as Kaposi's sarcoma (KS).

About a month after that first report, the write-up in the CDC's Morbidity and Mortality Weekly Report counted 26 gay men across New York and California with those diagnoses -- a number that would increase exponentially.

Saturday marked the 40th anniversary of the nation's first reported cases of AIDS.

More than 700,000 people in the US have died of the disease since then and though medical advancements have drastically changed the prognosis for HIV/AIDS patients, there remains to this day no cure.

President Joe Biden released a statement marking the anniversary and noting the work the US has done to combat the illness at home and around the globe.

He said he's asked Congress to provide $670 million to fight new HIV cases by increasing treatment, expanding the use of preexposure prophylaxis and ensuring equitable access to treatment.

"In honor of all those we have lost and all those living with the virus -- and the selfless caregivers, advocates, and loved ones who have helped carry the burden of this crisis, we must rededicate ourselves to reducing HIV infections and AIDS-related deaths," the President said in the statement.

"We must continue empowering researchers, scientists, and health care providers to ensure equitable access to prevention, care, and treatment in every community -- particularly for communities of color and the LGBTQ+ community."

Here's a look back at how the AIDS epidemic unfolded.

Activists drove the early response The early years of the AIDS epidemic were an uncertain and unsettling time.

LGBTQ communities were losing friends and loved ones to the disease, one after another -- with little idea as to how or why. All the while, it seemed society had turned a blind eye.

"Can you imagine what it must be like if you had lost 20 of your friends in the last 18 months?" Larry Kramer, famed AIDS activist and co-founder of the Gay Men's Health Crisis, said in a 1983 interview with the "Today" show.

"No cause, no cure, people in hospitals. It's a very angry community."

President Ronald Reagan's administration paid little attention to the epidemic, with four years going by before Reagan made a public mention of AIDS.

Exchanges between Reagan's press secretary and reporters in 1982 and 1983 indicate that the nation's top officials and mainstream society viewed the disease as a joke, and not an issue of great concern.

That stemmed from the perception of AIDS as a "gay plague", a condition thought to be tied to the lifestyles and behaviors of gay men, even though cases had also been reported in women, infants, those with hemophilia and people who injected drugs.

In a recently published interview with the New England Journal of Medicine, AIDS researcher Alexandra Levine spoke of "the horror of watching as society as a whole turned its back on this suffering, the horror of watching as many of my own colleagues refused to help, refused to care, refused to act as the professionals they were supposed to be."

As politicians and government entities proved slow to act, activists took matters into their own hands, doing what they could to combat homophobia and stigma and make sure their communities received the public health information they needed.

Scientists struggled to understand AIDS

In the early '80s, HIV/AIDS was considered a death sentence.

Scientists and physicians were struggling to understand what caused the disease and how it spread -- making the process of finding a treatment all the more challenging.

Dr. Anthony Fauci, who became director of the National Institute of Allergy and Infectious Diseases at the height of the AIDS epidemic, refers to that period of his career as the "dark years."

"I went from a person who was seeing patients with other diseases and developing cures and adequate therapies for them in the early part of my career, to every day taking care of people who inevitably were going to die, usually within a short period of time," he said in a recent interview with CNN.

Therapies came in the late '80s and '90s

The tide started to turn in the late '80s and '90s, as more effective therapies became available and transformed what it meant for an individual to live with HIV.

On March 19, 1987, the Food and Drug Administration approved an antiretroviral drug known as AZT to treat HIV infection.

By the late '80s and '90s, public perception of HIV/AIDS was also starting to shift -- thanks in part to high-profile activists and celebrities.

Princess Diana was also instrumental in shattering stigmas and myths around the illness, famously photographed visiting HIV/AIDS patients in hospital wards and shaking hands with them without gloves.

Another scientific breakthrough came in 1996, when the FDA approved the first protease inhibitors. That development brought into use what's known as highly active antiretroviral therapy (HAART), turning HIV/AIDS from a fatal diagnosis to a controllable condition.

Richard Chaisson, a physician who helped lead the fight against AIDS at Johns Hopkins University Hospital in the late '80s and '90s, described the feeling to the New England Journal of Medicine.

"Desperation changed to hope. Hope changed to belief, and belief changed to joy," he recalled. "So many patients returned home from the ship of the doomed and went back to living near-normal lives."

Despite the US setting a goal in 1997 to find an HIV vaccine within 10 years, four decades later, there is still no vaccine or cure.

Below | Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, talks to his team about HIV/AIDS during a meeting in 1990.